Dave Farber
2018-07-04 01:42:26 UTC
Subject: [Dewayne-Net] Routine DNA tests will put NHS at the 'forefront of medicine'
Date: July 4, 2018 at 10:29:41 AM GMT+9
Routine DNA tests will put NHS at the 'forefront of medicineâ
From 1 October new cancer patients will have tumours screened for key mutations
By Ian Sample
Jul 3 2018
<https://www.theguardian.com/science/2018/jul/03/nhs-routine-dna-tests-precision-cancer-tumour-screening>
People in England will have access to DNA tests on an unprecedented scale from the autumn when the NHS becomes the first health service in the world to routinely offer genomic medicine.
From 1 October, hospitals across England will be connected to specialist centres that read, analyse and interpret patient DNA to help diagnose rare diseases, match patients to the most effective treatments, and reduce adverse drug reactions.
The move marks a big step towards âprecision medicineâ, which offers more efficient therapies that are tailored to individual patients.
Under the service, new cancer patients will routinely have their tumour DNA screened for key mutations that can point doctors towards the best drug to use in treatment, or to clinical trials of experimental therapies that patients are likely to benefit from.
For some diseases, such as leukaemia, sarcoma and childhood malignancies, doctors will have the cancerâs whole genome sequenced to identify the suite of mutations that drive their growth. Similarly broad sequencing will be available for medical staff caring for babies and children who are admitted to intensive care without an existing diagnosis.
Beyond its aim to bring patients the most effective treatments faster, the service is expected to generate a wealth of data on the interplay between DNA, health and lifestyles, which will become a powerful tool for research into cancer and other diseases.
The genomic medicine service will launch in England initially, but discussions are under way with the devolved regions about how they might become involved.
âWe are ushering in a new era of genomic health,â said Mark Caulfield, the chief scientist at Genomic England and professor of cardiovascular genetics at the William Harvey Research Institute in London. âThis is a big step and it grows over the new two years. Itâs a total transformation.â
The NHS already provides some genetic tests but uptake has been patchy and depended on regional expertise, leading to stark differences in the tests available across the UK.
âThis will really look to address that. It wonât matter if you live in the north east [of England] or the south west, you should have the same access to clinical genome testing and thatâs a great thing,â said William Newman, professor of translational genomic medicine at Manchester University and vice-chair of the British Society for Genetic Medicine.
The service will build on foundations laid down by the 100,000 Genomes Project, a huge DNA sequencing effort run by Genomics England, a company formed by the Department of Health in 2013. So far the scientists have read more than 70,000 whole genomes of people with cancer or rare genetic diseases and expect to reach their target by the end of the year.
The project swiftly established that the standard surgical practice of preserving tumour biopsies in a solution of formaldehyde played havoc with DNA. To read the genetic makeup of a cancer the tissue must be fresh-frozen, a change of procedure that is steadily being adopted by surgeons.
Genomics England has set up seven genomic hubs across the country to deliver DNA tests on cancer, rare diseases and other conditions. A separate lab in Cambridge will perform whole genome sequencing when all 3.2bn letters of the human DNA code are needed. Because DNA test results are often complex, 13 national genomic medicine centres will draw on multidisciplinary teams of specialists to work through results and write reports for patients. Details of available tests will be stored in a national directory that will be updated every year as genetic medicine advances.
Genetic medicine has already transformed the treatment of some cancer patients. The drug Herceptin was developed to knock out proteins called oestrogen receptors that make some breast cancers grow faster. It takes a quick gene test to identify patients most likely to benefit. âIt shows in a nutshell the elegance and the potential of targeted therapies,â said Louise Jones, professor of breast pathology at Barts Cancer Institute in London.
[snip]
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-------------------------------------------Date: July 4, 2018 at 10:29:41 AM GMT+9
Routine DNA tests will put NHS at the 'forefront of medicineâ
From 1 October new cancer patients will have tumours screened for key mutations
By Ian Sample
Jul 3 2018
<https://www.theguardian.com/science/2018/jul/03/nhs-routine-dna-tests-precision-cancer-tumour-screening>
People in England will have access to DNA tests on an unprecedented scale from the autumn when the NHS becomes the first health service in the world to routinely offer genomic medicine.
From 1 October, hospitals across England will be connected to specialist centres that read, analyse and interpret patient DNA to help diagnose rare diseases, match patients to the most effective treatments, and reduce adverse drug reactions.
The move marks a big step towards âprecision medicineâ, which offers more efficient therapies that are tailored to individual patients.
Under the service, new cancer patients will routinely have their tumour DNA screened for key mutations that can point doctors towards the best drug to use in treatment, or to clinical trials of experimental therapies that patients are likely to benefit from.
For some diseases, such as leukaemia, sarcoma and childhood malignancies, doctors will have the cancerâs whole genome sequenced to identify the suite of mutations that drive their growth. Similarly broad sequencing will be available for medical staff caring for babies and children who are admitted to intensive care without an existing diagnosis.
Beyond its aim to bring patients the most effective treatments faster, the service is expected to generate a wealth of data on the interplay between DNA, health and lifestyles, which will become a powerful tool for research into cancer and other diseases.
The genomic medicine service will launch in England initially, but discussions are under way with the devolved regions about how they might become involved.
âWe are ushering in a new era of genomic health,â said Mark Caulfield, the chief scientist at Genomic England and professor of cardiovascular genetics at the William Harvey Research Institute in London. âThis is a big step and it grows over the new two years. Itâs a total transformation.â
The NHS already provides some genetic tests but uptake has been patchy and depended on regional expertise, leading to stark differences in the tests available across the UK.
âThis will really look to address that. It wonât matter if you live in the north east [of England] or the south west, you should have the same access to clinical genome testing and thatâs a great thing,â said William Newman, professor of translational genomic medicine at Manchester University and vice-chair of the British Society for Genetic Medicine.
The service will build on foundations laid down by the 100,000 Genomes Project, a huge DNA sequencing effort run by Genomics England, a company formed by the Department of Health in 2013. So far the scientists have read more than 70,000 whole genomes of people with cancer or rare genetic diseases and expect to reach their target by the end of the year.
The project swiftly established that the standard surgical practice of preserving tumour biopsies in a solution of formaldehyde played havoc with DNA. To read the genetic makeup of a cancer the tissue must be fresh-frozen, a change of procedure that is steadily being adopted by surgeons.
Genomics England has set up seven genomic hubs across the country to deliver DNA tests on cancer, rare diseases and other conditions. A separate lab in Cambridge will perform whole genome sequencing when all 3.2bn letters of the human DNA code are needed. Because DNA test results are often complex, 13 national genomic medicine centres will draw on multidisciplinary teams of specialists to work through results and write reports for patients. Details of available tests will be stored in a national directory that will be updated every year as genetic medicine advances.
Genetic medicine has already transformed the treatment of some cancer patients. The drug Herceptin was developed to knock out proteins called oestrogen receptors that make some breast cancers grow faster. It takes a quick gene test to identify patients most likely to benefit. âIt shows in a nutshell the elegance and the potential of targeted therapies,â said Louise Jones, professor of breast pathology at Barts Cancer Institute in London.
[snip]
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